Elevated RV-pulmonary arterial coupling on cardiac MRI in transfusion-dependent thalassemia associated with heart failure

In transfusion-dependent thalassemia, cardiac MRI RV-pulmonary arterial coupling was higher than in controls (0.68 vs 0.59; p<0.0001) and independently associated with heart failure (OR 3.99; p=0.049).

• In 1154 TDT patients, RVPAc was significantly higher than in 167 matched controls (0.68 ± 0.28 vs 0.59 ± 0.15; p < 0.0001).
• Higher RVPAc was associated with myocardial iron overload, higher liver iron concentration, and junctional late gadolinium enhancement.
• Multivariable analysis revealed that increased RVPAc was independently associated with greater odds of heart failure (OR 3.99; p = 0.049).

Automated summary

RadPigeon summaries are original and for information only. They are not clinical advice.