Helical 3D DSA Enables Single-Injection Whole-Head-and-Neck Angiography: First-in-Human Feasibility

Helical 3D DSA enabled single-injection whole-head-and-neck angiography (aortic arch to vertex) in a first human case, with 419.4 mm coverage in 7.6 sec, 11 lp/cm resolution, and 2.57% stenosis measurement error vs conventional DSA.

• The helical scan covered 419.4 mm in 7.6 sec, compared with 174.0 mm for conventional 3D DSA, while preserving 11 lp/cm spatial resolution.
• In two swine, undiluted contrast at 10 mL/sec yielded diagnostic-quality images with high interreader agreement (ICC >0.90 among three readers).
• In the first human patient, continuous angiography from aortic arch to cranial vertex was obtained, and stenosis agreement with conventional DSA had a mean absolute error of 2.57% ± 0.90.

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