Neighborhood Disadvantage Linked to Older Brain Age, Lower Volume on MRI

Patients in the most disadvantaged neighborhoods had brain age gaps 2.72–3.02 years higher, lower total brain volume, and more white matter hyperintensities on brain MRI, in a study of 2826 patients.

• The study analyzed cross-sectional brain MRI from a real-world clinical population without radiologic evidence of disease, using the Area Deprivation Index (ADI) to measure neighborhood disadvantage.
• Interaction models revealed that white matter hyperintensity volume was more strongly associated with reduced volumes in the striatum and dorsolateral prefrontal cortex among the most disadvantaged group.

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