AI Detects 39% More Intracranial Aneurysms on CTA than Radiologists Alone in Prospective Study

In 3,856 CTAs, an AI tool found 39% more intracranial aneurysms missed by radiologists (55 AI-only true positives), with AI sensitivity 0.846 vs radiologist 0.718. Specificity similar (0.985 vs 0.987). Gain-to-pain ratio 1.20, best in inpatients.

• Performance metrics estimated under a hybrid reference standard (only discordances adjudicated), which may bias absolute sensitivity and specificity.
• Operational metrics varied by setting: rEDR 78.3%, GPR 2.57 for inpatients vs rEDR 14.1%, GPR 0.67 for outpatients.
• Most AI-only aneurysms were <3 mm (56.4%), while radiologist-only were mostly 3–5 mm (54.5%).

Automated summary

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