Diffusion model improves crystal scatter recovery in high-resolution PET prototype

A diffusion model (D3Recovery) for inter-crystal scatter recovery in Prism-PET achieved 70.1% crystal identification accuracy for ICS events, reduced localization error from 2.18 mm to 0.99 mm, and improved DOI resolution to 3.6 mm FWHM. Image quality and uniformity also improve…

• In an ultra-micro Derenzo phantom, D3Recovery increased peak-to-valley ratio by 24% for ICS events vs. center-of-gravity positioning.
• For a Hoffman brain phantom, mean absolute error decreased by 17.84% for ICS events and structural similarity increased by 15.60%.
• Standard deviation in a uniform region fell by 20.88% for ICS events with D3Recovery, indicating reduced noise.

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