Immunotherapy Yields Durable MRI Responses in Perineural Spread of Cutaneous SCC

MRI surveillance of perineural spread from cutaneous SCC shows frequent durable response to anti-PD-1 immunotherapy: in a retrospective cohort of 9 patients, 3 had complete response, 5 partial, none progressed (median 37 mo). Literature review of 101 cases: 35% complete response.

• One patient in the cohort exhibited pseudoprogression — early MRI worsening followed by subsequent improvement — highlighting the need for caution in early post-treatment imaging assessment.
• In the pooled literature review of 101 patients, partial response rate was 43%, stable disease 9%, and progressive disease 10%; pseudoprogression was seen in 1%.

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