PI-RADS score independently tied to significant prostate cancer and upgrading in prostatectomy cohort

In 564 men undergoing MRI-targeted/fusion biopsy and radical prostatectomy, PI-RADS independently predicted clinically significant prostate cancer (68.3%) and biopsy-to-prostatectomy upgrading (29.1%), but model discrimination was limited, so it should be used with other paramet…

• Retrospective single-center study of 564 patients who had mpMRI-transrectal ultrasound fusion-guided biopsy followed by radical prostatectomy (2021-2025).
• PI-RADS score was significantly associated with clinically significant prostate cancer (ISUP Grade Group >= 2) and remained independently associated in multivariable analysis.
• Histopathological upgrading occurred in 29.1% (164/564); PI-RADS was independently associated with upgrading, but model discrimination was limited.

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