Swine model of intestinal embolization with imipenem/cilastatin shows consistent ischemia irrespective of heparin

In swine, intestinal embolization with imipenem/cilastatin produced ischemia irrespective of heparin (median pathological grade 3 both). Angiographic scores unchanged at 1-3h in 72.2%. Renal perfusion defects had minimal histologic damage.

• Regardless of heparin, all embolized intestinal segments showed ischemia; macroscopic grades were similar (median 3 vs 4).
• Renal embolization for comparison caused cortical perfusion defects on angiography but only minimal histologic damage.

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