DWI radiomics plus D-dimer predicts 90-day outcomes after thrombolysis for ischemic stroke

A combined model using DWI radiomics & D-dimer predicted 90-day post-thrombolysis outcomes in ischemic stroke with a test AUC of 0.862, outperforming clinical factors alone (p=0.036). No external validation.

• Optimism-corrected AUC was 0.838 (bootstrap) and 0.772 (cross-validation); the radiomics-only model had a test AUC of 0.857.
• D-dimer was an independent risk factor; decision curve analysis suggested higher net clinical benefit for the combined model.
• Single-center retrospective study (n=115) without external validation; multi-center validation is required.

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