7T MRS shows elevated motor cortex GABA in Parkinson's disease but not FDR-significant

At-rest primary motor cortex GABA was higher in mild-to-moderate Parkinson’s disease (32 patients) vs 28 controls on 7T MRS, but the difference did not survive FDR correction (pFDR=0.06). Inhibitory/excitatory ratio was also higher. Glutamate did not differ. Findings support 7T…

• Resting GABA concentrations were higher in PD (pFDR=0.06), but not statistically significant after correction for two primary metabolites.
• No significant differences in glutamate concentrations between groups.
• Motor task changes were underpowered and showed no group × condition interactions; caution required.

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