Review Highlights Synergy of Liquid Biopsy, Molecular Panels, and ACR TI-RADS in Thyroid Nodule Management

Liquid biopsy and molecular panels (Afirma, ThyroSeq), integrated with strain elastography, ACR TI-RADS, and 99mTc-MIBI scintigraphy, may reduce unnecessary thyroidectomies for indeterminate nodules, per a comprehensive review.

• The review assesses circulating tumor DNA, circulating tumor cells, extracellular vesicles, and non-coding RNAs as liquid biopsy analytes.
• Artificial intelligence, radiomics, and minimal residual disease monitoring are highlighted as emerging adjuncts.

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