Radiomics on noncontrast postmortem CT detects myocardial infarction with AUROC 0.817

Radiomics machine learning on noncontrast postmortem CT detected autopsy-confirmed myocardial infarction with mean AUROC 0.817 (55 MI, 51 controls); sensitivity 0.764, specificity 0.724. Supports forensic cause-of-death assessment but requires further validation.

• Support vector machine and random forest with no additional selection had comparable AUROC (0.814).
• Feature selection via random forest ranking or recursive feature elimination with logistic regression did not improve performance over no selection.
• The study was retrospective and the authors note potential clinical applications require further validation.

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