Regulatory B Cells and RPS2 Promote Bone Metastasis in Nasopharyngeal Carcinoma via Multi-Omics and Machine Learning

In nasopharyngeal carcinoma, regulatory B cells (Bregs) with high RPS2 expression were linked to bone metastasis. IL-10 secreted by Bregs activated PI3K/AKT and upregulated CXCR6 on tumor cells, attracting them to bone. Machine learning-derived prognostic signatures support Breg…

• Three machine learning algorithms (LASSO, random forest, Boruta) identified RPS2 as a prognostic gene in NPC bone metastasis.
• Animal models with intracardiac injection confirmed bone metastasis using bioluminescence, digital radiography, and micro-CT imaging.

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