Collagen-targeted MRI probe detects small lung cancers and metastases in preclinical study

Preclinical protein-based MRI agent targeting collagen detected small primary lung tumors and metastases to adrenal glands and kidneys in aggressive adenocarcinoma models. Collagen-targeted molecular MRI could enable radiation-free whole-body imaging and provide aggression clues…

• The agent, hProCA32.Collagen, binds type I collagen elevated in aggressive tumors and metastatic lesions, potentially reflecting tumor biology.
• In a model of aggressive lung adenocarcinoma with treatment-resistance mutations, it delineated primary lung tumors as well as adrenal and kidney metastases.
• A U.S. FDA investigational new drug application is being prepared; no human data yet.

Automated summary

RadPigeon summaries are original and for information only. They are not clinical advice.