CT radiomic features boost prediction of atrial fibrillation recurrence after radiofrequency ablation

In external validation of 236 patients, a CT radiomic model predicted AF recurrence post-ablation with AUROC 0.837 vs 0.722 for clinical, but fusion (0.848) did not significantly outperform radiomics alone.

• Retrospective multi-center study of 877 patients with AF undergoing radiofrequency ablation, with training, internal validation, and external validation cohorts.
• Radiomic model (AUROC 0.837) significantly improved discrimination over clinical model (0.722) in external validation; the fusion model (0.848) did not significantly outperform radiomics alone (DeLong P=0.43).
• Decision curve analysis showed net benefit, but calibration varied, and prospective validation is needed.

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