Stochastic NMF efficiently scales brain pattern analysis to 10,000 UK Biobank subjects, links structural covariance to visceral fat

A stochastic orthonormal projective NMF method analyzed 10,000 UK Biobank brain MRIs, identifying 20 structural covariance patterns; 13 in females and 11 in males showed significant links to visceral adipose tissue, mostly negative.

• The stochastic opNMF approach uses mini-batches, random compression, and repulsive point processes to dramatically reduce computational cost while retaining accuracy comparable to the original method (validated on 1,000 OASIS subjects).
• Applied to 10,000 UK Biobank participants, it derived 20 patterns of structural covariance (PSCs) and further refined them in higher-rank decompositions with 40 and 60 components.

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