High-Gradient Diffusion MRI Links Gray Matter Microstructural Decline to MS Disability

In MS patients, intra-soma signal fraction (fis) on high-gradient diffusion MRI was decreased in atrophy-prone gray matter, and correlated with disability (EDSS, ρ=-0.44, p<0.05), suggesting network-based neurodegeneration.

• High-gradient dMRI with SANDI modeling quantified intra-soma signal fraction (fis), a marker of gray matter cytoarchitecture.
• Decreased fis was observed in nodes of the Atrophy-based Functional Network (AFN) in MS vs controls.
• FDR-corrected covariance analysis showed inter-nodal correlations (ρ≥0.39), supporting a network-based neurodegeneration mechanism.

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