Brain Metastasis MRI Radiomics Yields Modest Survival Prediction Performance

In an external validation cohort of 69 brain metastasis patients, a T1 postcontrast MRI radiomics model achieved a C-index of 0.574 (95% CI 0.491-0.658) for overall survival prediction, suggesting limited standalone discrimination.

• Retrospective study using T1 postcontrast MRI radiomics with elastic-net Cox model, trained on 198 patients and externally validated on 69.
• Radiomics score alone yielded C-index 0.615 (95% CI 0.543-0.687) in training and 0.574 (0.491-0.658) in validation.
• Adding Graded Prognostic Assessment (GPA) to radiomics resulted in C-index 0.591 (0.509-0.672) in the validation subset.

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