Radiomics from a Single PET/CT Predicts Both Lymph Node Metastasis and PD-L1 in Non-Small Cell Lung Cancer

In a multicenter study of NSCLC, a PET/CT radiomics model predicted lymph node metastasis with AUC 0.845 (95% CI 0.716–0.973) and PD-L1 expression with AUC 0.776 (95% CI 0.641–0.911) from a single preoperative scan.

• For LNM, sensitivity was 0.765 (0.518–1.000) and specificity 0.786 (0.602–0.970) in temporal validation.
• For PD-L1, sensitivity was 0.800 (0.609–0.991) and specificity 0.650 (0.401–0.899).
• Radiomic signatures for LNM and PD-L1 were not significantly correlated, supporting the two-model approach.

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