Hippocampal PET texture asymmetry differentiates anti-LGI1 from anti-GABABR encephalitis

A hippocampal laterality radiomics model using 18F-FDG PET texture asymmetry achieved an AUC of 0.898 for differentiating anti-LGI1 from anti-GABABR encephalitis in a retrospective study of 82 patients.

• The asymmetry-based HLR model significantly outperformed radiomics models based on left, right, or bilateral hippocampal features alone (p<0.001).
• Sensitivity was 81.82% and specificity 87.50%; wavelet-derived GLSZM and GLRLM asymmetry features were the primary predictors.

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