Gut Microbiota Dysbiosis and Phospholipid Disturbances Tied to fMRI Brain Changes in Depressed Teens

In 160 depressed adolescents vs 90 controls, gut microbiota dysbiosis and disrupted glycerophospholipid metabolism were linked to fMRI brain alterations in precuneus and precentral gyrus. A multi-omics biomarker panel strongly predicted depression.

• Adolescents with depression had distinct gut microbial dysbiosis and pronounced disruption of glycerophospholipid metabolism.
• Resting-state fMRI showed abnormal functional reorganization and structure-function decoupling mainly in the precuneus and precentral gyrus.
• Mediation analysis suggested gut microbiota may influence depressive symptoms through glycerophospholipid metabolites and precentral gyrus dysfunction.

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