Enlarged basal ganglia perivascular spaces linked to sustained amyloid-β accumulation in Alzheimer's disease

Higher basal ganglia perivascular space burden on MRI was associated with sustained amyloid-β accumulation on follow-up PET in 524 ADNI participants (β=8.350, P=0.001). White matter PVS showed no link. Findings suggest BG-EPVS as a biomarker for amyloid trajectory.

• The annual rate of change in amyloid PET SUVR followed an inverted U-shape relative to baseline amyloid burden.
• White matter perivascular space volume fraction showed no association with amyloid accumulation rate.
• Deep-learning segmentation was used to quantify PVS volume fraction from structural MRI.

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