UK Biobank study links obesity to lower renal corticomedullary T1 differentiation

In 4214 UK Biobank adults, higher obesity (body roundness index) was associated with reduced renal corticomedullary T1 differentiation (ΔT1; β = -8.507, 95% CI -11.893 to -5.120), mainly from lower medullary T1, while age correlated with higher cortical T1.

• Both body roundness index and BMI were inversely associated with medullary T1 and cortical T1, with a stronger effect on medullary T1 driving reduced ΔT1.
• Age was positively associated with cortical T1 but not medullary T1, suggesting distinct effects of aging versus obesity on renal T1 values.

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