Super-Resolution CEUS Accurately Grades Crohn Disease Activity

Super-resolution contrast-enhanced US (SRCEUS) differentiated moderate/severe from remission/mild Crohn disease with AUC 0.92, sensitivity 94.1%, and specificity 95.0% in a prospective study of 54 patients. Performance exceeded conventional CEUS (AUC 0.78, P=.03).

• SRCEUS vascular density ratio was higher in moderate/severe disease (73.2% vs 38.5%, P<.001).
• A combined model with clinical, B-mode, CEUS, and SRCEUS parameters achieved AUC 0.94, outperforming color Doppler (AUC 0.82, P=.04).

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