MRI-guided PET reconstruction improves amyloid scan reader agreement and specificity

MRI-guided amyloid PET reconstruction improved interreader agreement (Fleiss κ 0.91 vs 0.79) and specificity (99.2% vs 91.6%), reducing false positives from 8.1% to 0.8% vs OSEM in a retrospective study of 120 patients.

• The greatest interreader agreement improvement was in the posterior cingulate cortex and precuneus (κ 0.82 vs 0.74, P=.03).
• Centiloid separation was preserved, and Aβ-negative scans had lower median Centiloid values with MRI-guided reconstruction (-4.24 vs 0.84, P=.01).
• The consensus-derived reference standard was not fully independent, representing a study limitation.

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