Advances in MPI: System Architectures, Tracer Engineering, and Clinical Translation

MPI is an emerging imaging modality providing real-time, quantitative visualization with no background and high sensitivity. This review covers MPI system architectures, rational tracer engineering via a Core-Shell-Function framework, and clinical applications such as cell track…

• MPI exploits the nonlinear magnetization of superparamagnetic iron oxide nanoparticles to produce real-time, quantitative images with zero tissue background and depth-independent signal.
• System configurations span closed-bore preclinical scanners to open, single-sided, hand-held, and hybrid designs, each with distinct scaling and sensitivity trade-offs.
• Rational tracer engineering via a Core-Shell-Function framework—optimizing core magnetism, surface coating, and functionalization—drives signal generation and in vivo performance for tasks like cell tracking and angiography.

Automated summary

RadPigeon summaries are original and for information only. They are not clinical advice.