External validation of coronary CTA AI for heart failure detection in NSTE-ACS

AI on coronary CTA in 1009 NSTE-ACS patients: 99% NPV for in-hospital heart failure; high AI likelihood group (17%) had a 5.39-fold risk (95% CI 2.32-12.50) of index HF, and 2.56-fold risk after discharge.

• In 1009 NSTE-ACS patients, the AI algorithm (external validation, no retraining) classified 17% as high HF likelihood.
• For in-hospital heart failure, NPV was 99%; high-risk group had subdistribution HR 5.39 (95% CI 2.32-12.50).
• After discharge, high AI likelihood was associated with post-discharge HF hospitalization (sub-HR 2.56, 95% CI 1.34-4.90).

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