Brain Network Dynamics on rs-fMRI Differ Between Parkinson's Disease and Progressive Supranuclear Palsy

Opposite brain network dynamics on resting-state fMRI distinguish Parkinson's disease from progressive supranuclear palsy, with machine learning achieving moderate accuracy. External validation needed.

• PD and PSP exhibited opposite trends in fraction occurrence of unimodal network-dominant brain states.
• PSP showed prolonged dwell time in the dorsal attention and limbic network state; reduced unimodal state occupancy correlated with cognitive decline in both groups.
• External multicenter validation is required before clinical application.

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