Dual-Sequence CT-Based AI Detects LV Myocardial Scar: Validation vs. Cardiac MRI

Multimodal AI combining dual-sequence CT, clinical, and echocardiographic data detected left ventricular myocardial scar with AUC 0.91, using cardiac MRI as reference in a retrospective study.

• CCTA radiomics alone achieved patient-level AUC 0.85 in the full cohort of 533 patients.
• In the dual-sequence subgroup (n=257), adding clinical and echocardiographic features to CT data improved AUC to 0.91.
• Segmental analysis with combined CCTA-CAC model yielded AUC 0.80 for scar regions in patients with known myocardial scar.

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