Education Moderates Alzheimer's Biomarker-Cortical Thickness Relationship in Women with Cognitive Decline

In a study of 80 patients, women with cognitive decline and lower education showed preserved cortical thickness despite higher p-tau/Aβ42 ratio (p=0.026) and thicker frontal cortex (p=0.049). Education moderated the biomarker-thickness link (p<0.05 for all regions), suggesting M…

• In females, high education was associated with expected cortical thinning with higher p-tau/Aβ42, while low education was linked to preserved thickness; this moderation was significant in all five brain regions (p<0.05).
• The preserved cortical thickness in lower-educated women did not mediate better cognitive performance, suggesting pathological resilience without functional benefit.
• The analysis was restricted to women because of substantial confounding between sex and education in this South Korean cohort, reflecting historical educational disparities.

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