Call for Harmonized Pediatric Proton MRS: A Minimum Standard for Neurometabolic Diagnosis and Monitoring

Spectroscopists propose a harmonized minimum-standard single-voxel proton MRS approach for children with neurodevelopmental delays, aiming to reduce misdiagnosis in cerebral creatine deficiency syndromes and standardize data for clinical trials.

• Issued by spectroscopists in collaboration with the Association for Creatine Deficiencies (ACD).
• Recommends a single-voxel proton MRS acquisition and post-processing protocol that can be implemented across vendors.
• Aims to reduce misdiagnosis of cerebral creatine deficiency syndromes and facilitate treatment monitoring and clinical trial data aggregation.

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