Iodine-124 evuzamitide PET shows 94% sensitivity and 86% specificity for cardiac amyloidosis

In the REVEAL study, the investigational PET tracer iodine-124 evuzamitide demonstrated 94% sensitivity and 86% specificity for detecting cardiac amyloidosis. Diagnostic performance remained high for both transthyretin (96% sens) and light-chain (95% sens) subtypes.

• The primary endpoint was met: on majority read of three independent readers, sensitivity was 94% and specificity was 86% for visual detection of cardiac amyloidosis.
• For the two major subtypes, sensitivity was 96% for transthyretin amyloidosis and 95% for light-chain amyloidosis, both with 86% specificity.

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