IMWG Issues Updated Recommendations for Solitary Plasmacytoma Diagnosis and Management

~50% of solitary plasmacytomas progress to symptomatic myeloma within 5 years. Updated International Myeloma Working Group recommendations emphasize advanced imaging to rule out systemic disease; local radiotherapy remains mainstay therapy.

• The diagnosis of solitary plasmacytoma requires meticulous exclusion of multiple myeloma using advanced imaging (whole-body MRI, PET/CT), sensitive marrow assessment, and serologic tests.
• Approximately 50% of cases progress to symptomatic myeloma within 5 years, and more sensitive detection tools now influence follow-up strategy.
• Local radiotherapy remains the cornerstone of treatment; the benefit of systemic therapy for myeloma is still unproven in this setting.

Automated summary

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