NaF-PET Detects Arterial Microcalcification Years Before CT Calcium

Sodium fluoride (NaF) PET visualizes active arterial microcalcification below the resolution of CT, years before macrocalcification appears. This allows clinicians to monitor early response to statins or PCSK9 inhibitors, even when CT calcium scores stay unchanged.

• NaF binds to hydroxyapatite surfaces, detecting microscopic mineral deposits that precede CT-visible plaque.
• Anti-atherosclerotic therapy can reduce NaF uptake without altering CT calcium scores, demonstrating a treatment-monitoring window.
• Emerging AI-based quantification may further enhance NaF-PET's role in tracking early atherosclerosis.

Automated summary

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