Phantom-corrected DCE-MRI predicts pancreatic cancer chemo-response at 7 weeks with 98% accuracy

Quantitative DCE-MRI predicted 17-week pancreatic cancer chemotherapy response with 98% accuracy after 7 weeks, after phantom correction (extended Tofts model). Earlier CT RECIST identified only 17% responders.

• After point-of-care perfusion phantom (P4) correction, the extended Tofts model achieved 98% predictive accuracy.
• Standard CT RECIST at 8 weeks identified response in only 17% of patients.
• Prospective study of 42 patients across two institutions.

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