Brain FDG PET Shows Thalamic Hypermetabolism in Chemotherapy-Naïve Breast Cancer Fatigue

In 20 chemotherapy-naïve breast cancer patients with cancer-related fatigue, brain FDG-PET showed hypermetabolism in bilateral thalamus (T=-2.23, P=0.05) and hypometabolism in right anterior cingulate gyrus (T=2.28, P=0.05).

• Paired FDG PET/CT scans on a high-sensitivity Biograph Vision Quadra scanner were analyzed with an atlas-based ROI approach.
• Trends toward altered metabolism were noted in the right globus pallidus, right amygdala, and retrosplenial cortex but were not significant.

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