Automated single-slice CT body composition predicts survival in liver cancer as well as volumetric analysis

In 448 patients with newly diagnosed HCC, automated single-slice L3 muscle index and attenuation independently predicted overall survival (HR 1.63 & 1.38). Volumetric analysis did not improve discrimination (C-index 0.816 vs 0.817, p=0.11). Single-slice is a practical alternativ…

• Strong correlations (≥0.82) between volumetric and single-slice measurements for muscle attenuation, visceral fat index, and subcutaneous fat index, but only moderate (0.50) for muscle index.
• Single-slice low muscle index (HR 1.63, 95% CI 1.15-2.31), single-slice low muscle attenuation (HR 1.38, 1.01-1.88), and volumetric low muscle attenuation (HR 1.42, 1.03-1.95) were independent predictors of overall survival.

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