Wayne State team wins $2.54 million NCI grant for glioblastoma PET tracer

A $2.54 million National Cancer Institute grant supports development of a fluorine-18 PET tracer that targets tryptophan metabolism to reveal active glioblastoma beyond conventional MRI and guide treatment.

• Five-year project targets the tryptophan-kynurenine pathway used by glioma cells to evade immunity.
• Fluorine-18 tracer replaces carbon-11 to overcome short half-life limitations and enable broader clinical use.
• PET/CT quantitative maps may help define tumor extent, guide surgery, and distinguish recurrence from treatment effects.

Automated summary

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