Connectome-based modeling of suicidality: disrupted prefrontal-limbic circuitry and reduced global integration

Suicidal thoughts and behaviors are tied to disrupted prefrontal-limbic-subcortical circuitry and reduced global brain network integration on MRI; connectome profiles may act as individual 'fingerprints' to guide personalized risk assessment.

• The review also covers PET and EEG/MEG findings, pointing toward multimodal connectomic research.
• Connectome-based machine learning and normative models are proposed as a route to a suicide risk calculator.
• Authors emphasize the need for high-quality longitudinal cohorts for validation.

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