Peripheral tumor fluidity on multifrequency MRE predicts pancreatic cancer survival

In 96 treatment-naive pancreatic cancer patients, higher peripheral tumor fluidity on multifrequency MR elastography independently predicted shorter disease-free survival after R0 resection (HR 2.15, 95% CI 1.03–4.50) and correlated with tumor stage, perineural invasion, nodal a…

• Peripheral tumor fluidity was higher than central fluidity (1.23 ± 0.25 vs 0.95 ± 0.19 rad; p < 0.001), while stiffness showed no zonal difference (p = 0.07).
• Peripheral fluidity correlated with higher tumor stage (ρ = 0.28), perineural invasion (ρ = 0.31), regional lymphadenopathy (ρ = 0.29), and distant metastasis (ρ = 0.26).
• In 48 R0-resected patients, higher peripheral fluidity was associated with shorter disease-free survival (9.1 vs 19.4 months; p = 0.009) and was an independent predictor (HR 2.15).

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