EndoFusion: Unpaired multi-modal AI detects endometriosis signs on TVUS and MRI

EndoFusion, an unpaired multi-modal AI framework, detected endometriosis signs (POD obliteration, bowel nodules) on TVUS and MRI with average AUC 0.827 (95% CI 0.790–0.861).

• EndoFusion enables detection of pouch of Douglas obliteration and bowel nodules from either transvaginal ultrasound or MRI alone, without needing paired exams.
• The framework uses dynamic mutual knowledge distillation and label correlation modeling to transfer knowledge across modalities and signs.
• Single-institution proof-of-concept study; external validation not yet performed.

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