Combining PET hypometabolism and MRI atrophy maps with clinical data improves prediction of seizure freedom after temporal lobe epilepsy surgery

A preoperative model integrating 18F-FDG PET hypometabolism and MRI atrophy patterns with clinical factors predicted 1-year seizure freedom after temporal lobe surgery with an AUC of 0.63–0.70, outperforming imaging-only models.

• The study retrospectively analyzed 101 patients (72 lobectomies); left and right TLE showed distinct spatial divergences between hypometabolism and atrophy.
• Adding postoperative resection volume did not significantly boost predictive performance beyond the preoperative imaging-clinical model.
• The models remain exploratory; external validation in multi-center cohorts is needed before clinical translation.

Automated summary

RadPigeon summaries are original and for information only. They are not clinical advice.