Osteoporosis medication after vertebral augmentation linked to 6-fold lower refracture risk

Only one-third of patients received osteoporosis medication after vertebral augmentation. The incidence of new vertebral fractures fell from 0.519 to 0.076 per person-year after starting medical management (incidence rate ratio 6.79, 95% CI 3.37-15.51), a 6-fold decreased risk.

• In a retrospective cohort of 249 patients, only 33.3% received standard-of-care osteoporosis medical management (MM) after vertebral augmentation, initiated at a mean of 6.09 months post-procedure.
• Multivariable logistic regression identified MM and age as the only patient or procedural factors significantly associated with refracture risk.
• The single-center, retrospective design may limit generalizability and does not establish causality.

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