Elevated SII associated with malignancy in Lung-RADS 4 lung nodules

Higher systemic immune-inflammatory index (SII) was associated with malignancy in Lung-RADS 4 lung nodules on LDCT: adjusted difference +272 (95%CI 75-470, P=0.007) and OR 3.74 for SII >561.

• Retrospective single-center study of 123 patients with Lung-RADS 4 nodules (63.4% malignant).
• After multivariable adjustment, malignant nodules had a significantly higher SII (mean difference +272, 95% CI 75-470, P=0.007).
• Using SII cutoff 561, high SII conferred an odds ratio of 3.74 for malignancy (95% CI 1.42-9.85, P=0.008).

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