MRI Clustering Reveals Two Distinct Cortical Aging Trajectories in Healthy Older Adults

In 176 healthy adults aged 68-85, longitudinal MRI clustering identified two groups: one with minimal atrophy and one with more pronounced left prefrontal/central atrophy. The atrophic cluster was linked to lower education and trended with cognitive decline.

• The atrophic cluster showed more cortical thinning in left prefrontal and central regions, while the other cluster had minimal change.
• Education was significantly associated with cluster membership in univariate analysis (borderline significance after adjustment).
• No significant differences in age or sex were found between the two clusters.

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