QSM Reveals Limbic White Matter Susceptibility Increases in Preeclampsia

Women with preeclampsia had significantly higher susceptibility in temporal cingulum (left: 15.75 vs 9.95 ppb; right: 14.86 vs 8.48 ppb) and left fornix (5.07 vs 1.14 ppb) on quantitative susceptibility mapping (QSM) MRI compared with pregnant controls in a cohort of 350 women.

• In adjusted models, preeclampsia was associated with higher susceptibility in bilateral temporal cingulum and left fornix (β=0.246–0.386; p<0.05).
• Susceptibility values correlated weakly with circulating hypoxia-inducible factor-1α and total tau (ρ≈0.22–0.27).
• Exploratory postpartum findings (n=32) require confirmation in larger longitudinal cohorts.

Automated summary

RadPigeon summaries are original and for information only. They are not clinical advice.