A geroscience framework for non-surgical knee OA treatments and GAE

For knee OA, weight loss, exercise, and education remain core interventions for preserving joint healthspan. Genicular artery embolization may help in synovitis-dominant cases but lacks consistent sham-controlled evidence.

• Weight reduction, exercise, and education are core joint healthspan interventions with consistent evidence for pain relief and functional benefit.
• Genicular artery embolization (GAE) targets synovitis/hypervascularity-dominant KOA but lacks consistent sham-controlled evidence.
• Future trials should differentiate symptomatic relief from true modification of joint aging biology.

Automated summary

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