Beyond Morphology: Imaging Biological Features of Liver Metastases

Imaging evaluation of liver metastases is evolving from purely morphologic assessment to biologically informed techniques. Advanced imaging, radiomics, and artificial intelligence can assess tumor biological heterogeneity, guide therapy, and predict outcomes.

• Classical imaging determines presence, number, location, and resectability; newer approaches assess biological characteristics for treatment strategy.
• Radiomics and AI enhance predictions of therapeutic response and outcomes by analyzing tumor heterogeneity.
• Review covers imaging features suggestive of primary malignancies and atypical presentations.

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