XGBoost accurately localizes cerebral artery territorial infarcts on non-contrast CT in acute stroke

In acute ischemic stroke, XGBoost predicted anterior (ACA), middle (MCA), and posterior (PCA) cerebral artery territorial infarcts on non-contrast CT with AUCs of 0.92, 0.87, and 0.95, respectively (n=118). Mean cross-validated AUC 0.94±0.03.

• XGBoost AUCS: 0.92 (ACA), 0.87 (MCA), 0.95 (PCA); cross-validated mean AUC 0.94±0.03.
• For left/right/bilateral classification, XGBoost outperformed logistic regression (mean AUC 0.90 vs 0.82, p<0.01).
• Mild overfitting was noted; future multi-center external validation is required.

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