Larger MRI Infrapatellar Fat Pad Volume Associated with Less Cartilage Damage in Knee OA

Cross-sectional OAI study (n=4,257): larger DL-derived infrapatellar fat pad volume on MRI associated with greater patellofemoral cartilage thickness (+0.011 mm/cm³) and less cartilage damage, BMELL, and meniscal tears in lateral compartments.

• Larger IPFP volume was associated with lower cartilage lesion WORMS scores in the patella (β = -0.036, 95% CI -0.061 to -0.010), lateral femur (β = -0.058, -0.076 to -0.039), and lateral tibia (β = -0.079, -0.099 to -0.060).
• Larger IPFP volume was also associated with lower bone marrow edema-like lesion scores in the lateral tibia (β = -0.027, -0.036 to -0.018) and lower lateral meniscus scores (β = -0.054, -0.070 to -0.037).

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